Download Epilepsy: Mechanisms, Models, and Translational Perspectives by Jong Rho,Raman Sankar,Carl E. Stafstrom PDF

By Jong Rho,Raman Sankar,Carl E. Stafstrom

Epilepsy has stricken humankind all through recorded heritage; but, it is just within the final half-century, that major development has been made in our uncomplicated figuring out of the epileptic mind. Pivotal advances in drug improvement and surgical concepts, in addition to the emergence of cutting edge techniques comparable to electric stimulation of the fearful method, have resulted in a considerable aid within the morbidity and mortality of sufferers with epilepsy. whilst, awesome advancements in neuroscience have more advantageous our realizing of mind constitution and function.

Epilepsy: Mechanisms, versions, and Translational views incorporates new translational advances that carry epilepsy cures from the laboratory bench to the bedside and again back. It brings jointly the paintings of greater than 70 of the field’s most valuable and state of the art researchers and clinicians. In 24 chapters, this terribly accomplished and present work:

Offers an outline of the fundamental anatomic and useful substrates of seizure genesis and considers novel pathogenic ideas that experience either emerged and been confirmed experimentally

  • Examines antiepileptic drug treatment, together with the newest on molecular goals

  • Looks on the kingdom of surgical remedies for epilepsy and discusses advances within the fields of structural and practical neuroimaging

  • Reviews the diversity of nontraditional healing concepts, equivalent to the ketogenic nutrition, the vagus nerve stimulator, immunomodulators, neurosteroids, herbs, and botanicals

  • Investigates neuroendocrine, hormonal, and biobehavioral components that effect seizure susceptibility—information that may be included into the layout of remedy algorithms on an individualized foundation

  • Provides a glimpse of what destiny epilepsy treatments may seem like, from novel mechanisms of drug supply to gene and stem-cell remedies for epilepsy to seizure detection equipment, to the final word aim of affliction prevention.

The proposal for this e-book was once encouraged by way of the editors’ collective wish to advertise bridging of the so-called translational divide—that is, protecting cutting edge remedy innovations in accordance with clinical rules that experience but to be confirmed conscientiously within the medical atmosphere, yet but may supply practitioners with new and promising methods towards epilepsy therapeutics.

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